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The trial will be conducted at three Chinese medicine clinics in Hong Kong. The results of this study will establish robust clinical evidence about the efficacy and safety of mXFP in the treatment of CU. A specific feature of this trial is that it is a integrative medicine trial with subjects being allowed to take the Western and Chinese medicine together for the treatment. Trial registration This is registered on ClinicalTrials.gov, ID NCT04967092. Register date July 19, 2021. https//clinicaltrials.gov/ct2/show/NCT04967092 . The results