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After adjusting for other potential co-factors, diabetes did not constitute a risk factor neither in the whole series (HR 1.12, 95% IC 0.78-1.51; P=0.26) nor in alcoholic (HR 1.160, 95% CI 0.74-1.82; P=0.5 or HCV cirrhosis (HR 1.17, 95% CI 0.63-2.19; P=0.6. These figures did not change after excluding patients treated with metformin. In Caucasian patients with alcoholic or HCV cirrhosis, diabetes is not a risk factor for developing HCC. This lack of association does not seem to be consequence of the protective effect of metformin. I
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