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The aim of this work is to explore 132La as a PET imaging surrogate of 225Ac using a DOTA-based, tumor-targeting alkylphosphocholine (NM60. La was produced on a biomedical cyclotron. For in vivo experiments, mice bearing 4T1 tumors were administered [ La]-NM600, and PET/CT scans were acquired up to 24h post-injection (p.i.). Following the last timepoint, ex vivo tissue distribution was measured to corroborate in vivo PET data. Ex vivo tissue distribution was performed at 4h and 24h p.i. in mice injected with [ Ac]-NM600. PET/CT images