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To investigate the influence of reducing material thickness on flexural properties of computer-aided design and computer-aided manufacturing (CAD-CAM) denture base resins. Four CAD-CAM denture base acrylic resin materials were selected; two were made via the subtractive method (AvaDent and IvoCad) and two were made with the additive method (FormLabs and NextDent). One heat-polymerized denture base material was used as a control. Specimens were fabricated with varying thicknesses (n = 10/group) 3.3 mm, 2.5 mm, 2 mm, or 1.5 mm. Flexural st