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The cohort rate ratio followed an inverted U-shaped pattern and was highest in 1951-1955 birth cohort. The MDD data were estimated and wide social factors were not included in the analyses. The changes of MDD incidence rate in China are likely to be related to rapid social and economic development, and major historical events. However, the associations need to be interpreted with caution. The changes of MDD incidence rate in China are likely to be related to rapid social and economic development, and major historical events. However, the associations need t

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