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Finally, we used isobologram analysis to compare combinations of the ELQs with either proguanil or atovaquone. We show that all quinolone combinations with proguanil are synergistic against P falciparum However, against P knowlesi, no evidence of synergy between proguanil and the quinolones was found. Importantly, combining the novel quinolone ELQ-300 with atovaquone, was synergistic against both species. Our data identify potentially important species differences in proguanil susceptibility and its interaction with quinolones, and supp
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