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TBA - additionally known as HD1, a 15-mer G-quadruplex (G4)-forming oligonucleotide - is the greatest characterized thrombin binding aptamer, in a position to specifically recognize the necessary protein exosite we, hence inhibiting the transformation of dissolvable fibrinogen into insoluble fibrin strands. Unmodified nucleic acid-based aptamers, as a whole, and TBA in