https://tamoxifenchemical.com/....a-suggested-abcd-sco
Many BTK inhibitors have been found to treat cancer and arthritis rheumatoid, including a series of BTK inhibitors centered on 8-amino-imidazo[1,5-a]pyrazine we recently reported. The X-ray crystal structures of BTK with inhibitors had been also posted, which supplied great help for the SAR design. Here we report our SAR work launching ring constraints for the 3-position piperidine amides on the BTK inhibitors based on 8
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