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87; p = 0.0001). We also identified relationships of adipocyte hypertrophy and macrophage infiltration with prognostic factors, such as cancer stage and tumour grade (p 0.05). RNA expression of pro-inflammatory cytokines (IL6, TNF) and leptin was also increased as a function of adipocyte size and CD86+/CD11c+ macrophage number/100 adipocytes (p 0.05). Our findings support the model of dysfunctional adipose tissue in obesity-associated breast cancer. Our findings support the model of dysfunctional adipose tissue in obesity-assoc
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