https://www.selleckchem.com/
These variants also exhibited reduced K and V values. An increase in their Km values, leading to a decreased catalytic efficiency (the K /K ratio) of autolytic and mixed variants. Moreover, in the variant with A59T mutation, K and V values have reduced compared to wild type. The mix variants showed the most increase in Km value (almost 2-fold) as well as reduced enzymatic affinity to the substrate. Thus, the results indicated that combined mutations at the ocriplasmin sequence were more effective compared with single mutations. The results indicated such va
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