https://aurorasignaling.com/yo....ur-exciting-world-of
These abide by the axon, concentrating voltage-dependent salt channels at nodes of Ranvier and patterning the encompassing axon into distinct molecular domains. The indicators in charge of developing and maintaining the complex structure of paranodal myelin are poorly grasped. Right here, we try the hypothesis that the planar cell polarity determinant Vangl2 organizes paranodal myelin. We show that Vangl2 is concentrated at paranodes and therefore, after conditional knockout of Vangl2 in oligodendrocytes, the paranoda
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