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83, 95% confidence interval [CI] 2.03-3.93, concordance index [c-index] = 0.68, median years-to-BCR 1.7). Histotyping was also prognostic in clinically stratified subsets, such as patients with Gleason grade group 3 (HR = 4.09) and negative surgical margins (HR = 3.26). Histotyping was prognostic independent of grade group, margin status, pathological stage, and preoperative prostate-specific antigen (PSA) (multivariable p less then 0.001, HR = 2.09, 95% CI 1.40-3.10, n = 648). The combination of Histotyping, grade group, and preoper
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