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The reported iPSC outlines might be a helpful tool for in vitro modeling of laminopathies involving LMNA genetic variations. V.Cisplatin is an efficient anticancer utilized widely in remedy for solid and germ cell tumors, however, the immense poisoning on healthier tissues discourages cisplatin use in prolonged treatment protocols. Testicular toxicity is amongst its undesired negative effects. Nilotinib is an extra generation multityrosine kinase inhibitor which is used as an anti