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All data analyses will likely to be carried out based on the intention-to-treat concept. ETHICS AND DISSEMINATION All study procedures being approved because of the Ethics Committee of Ulm University (application No. 48/18). The results is likely to be disseminated commonly through peer-reviewed magazines and conference presentations. TEST REGISTRATION QUANTITY DRKS00014701. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See legal rights and
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