https://www.selleckchem.com/pr....oducts/nvp-bsk805.ht
TGFβ-stimulated ILC2 also increased myofibroblast differentiation. Thus, human KLRG1 ILC2 had an enhanced profibrotic activity. In a mouse model of SSc, therapeutic intervention-combining pirfenidone with the administration of IL10 was required to reduce the numbers of skin infiltrating ILC2, enhancing their expression of KLRG1 and strongly alleviating skin fibrosis. Our results demonstrate a novel role for natural ILC2 and highlight their inter-relationships with TGFβ and IL10 in the development of skin fibrosis, thereby opening up
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