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In the 7th and 14th days, the traveled distance of rat was assessed because of the open-field test. Serum D-xylose content was based on the phloroglucinol method and interleukin (IL)-10 and IL-17 levels had been measured utilizing an enzyme-linked immunosorbent assay kit. The information of Treg cells was dependant on circulation cytometry. Combinations of endocrine treatment (ET) and targeted treatment (CDK4/6 or mTOR inhibitors) are standard of take care of HR+/HER2- metastatic
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