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Toxic epidermal necrolysis (TEN), nevertheless, is a life-threatening reaction that really needs treatment discontinuation. The current case shows the slow progression from a pemetrexed and carboplatin-associated maculopapular rash to a TEN-like response. © the writers; licensee ecancermedicalscience.Background Malignant transformation of mature cystic teratomas (MCTs) is an uncommon event. The most typical histology of a malignant change is squamous cell carcinoma, and you