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The intense irritation at 24 h after intratracheal instillation of MWCNTs to rats at 0.19, 0.63, and 1.91 mg MWCNT/kg weight (bw) or fiber-free supernatants from MWCNT suspensions at 1.91 and 7.64 mg MWCNT/kg bw showed that the number of granulocytes, a marker for acute irritation, ended up being dramatically increased with a good dose-dependency. The correlation research showed that neither the amount of metal nor the ROS generation potential of the dissolvable fractions revealed any correlations with all th
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