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with increased risk of AFS (HR 1.16; 95% CI, 0.91-1.47; P=0.238), or loss of primary patency (HR 1.04; 95% CI, 0.79-1.37; P=0.767). DM and ESRD each independently predict early and late major adverse limb events after an infrainguinal bypass in patients presenting with CLTI. However, in the presence of ESRD, DM may increase perioperative adverse events but does not influence primary patency and AFS at one year. The risk profile associated with ESRD appears to supersede that of DM, with no additive effect. DM and ESRD each independently p

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