https://bucladesineactivator.c....om/standard-of-livin
Its dysregulation is implicated in muscle wasting diseases. SRK-015 is a clinical-stage monoclonal antibody that prevents extracellular proteolytic activation of pro- and latent myostatin. Right here, we utilized incorporated structural and biochemical methods to elucidate the molecular process of an antibody-mediated neutralization of pro-myostatin activation. The crystal framework of pro-myostatin in complex with 29H4-16 Fab, a high-affinity variation of SRK-015, at 2.79 Å resolution
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