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To conclude, α-mannosyl-functionalized ManNP direct NP towards M2-type macrophages in diseased livers and steer clear of unspecific uptake in non-target cells. ManNP are promising vehicles for siRNA and other drugs for immunomodulatory remedy for liver fibrosis and liver cancer.Cancer is a multi-step process and needs constitutive expression/activation of transcription facets (TFs) for development and success. Lo