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The 4-azaindoline products bearing several substrates were gotten in excellent yield (90-99%), with a high enantioselectivity (up to 95%) and diastereoselectivity (up to 991).Drug precipitation when you look at the nephrons associated with kidney could cause drug-induced crystal nephropathy (DICN). To aid minimization for this risk at the beginning of medicine finding, we created a physiologically based in silico design to predict DICN in rats, p

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