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The characterization of these phenotypes and their particular main etiologies is paramount, particularly their hereditary components. In this study, TR-MDD patients (n = 124) were recruited and metabolites had been quantified inside their cerebrospinal substance (CSF) and peripheral bloodstream. Three sub-categories of inadequacies were examined, particularly 5-methyltetrahydrofolte (in CSF; n = 13), tetrahydrobiopterin (in CSF; n = 11), and abnormal acylcarnitine profiles
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