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BACKGROUND AND PURPOSE Early white matter (WM) changes and cortical atrophy in Huntington's disease (HD) are often evident before disease onset and extend through the brain during manifest stages. The trajectory of these brain abnormalities in symptomatic stages remains relatively unexplored. The aim of this study is to investigate how the pattern of WM and gray matter (GM) alterations progress over time. METHODS We investigated alterations in brain WM, cortical thickness, and subcortical structures using diffusion and structural magnet
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