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12, 95% CI= 1.01-1.24], asthma [RR=1.26, 95% CI= 1.06-1.50], type 2 diabetes mellitus [RR=1.22, 95% CI= 1.07-1.38]), and previous severe laboratory-confirmed coronavirus disease 2019 (RR=1.20, 95% CI= 1.03-1.39). To the best of our knowledge, this is the first study evaluating disease outcomes in a large set of laboratory-positive cases of symptomatic SARS-CoV-2 reinfection, and factors associated with illness severity were characterized. Our results may contribute to the current knowledge of SARS-CoV-2 pathogenicity and to identify pop

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