https://www.selleckchem.com/pr....oducts/wortmannin.ht
BACKGROUND Mitochondrial progressive external ophthalmoplegia (PEO) encompasses a broad spectrum of clinical and genetic disorders. We describe the phenotypic subtypes of PEO and its correlation with molecular defects and propose a diagnostic algorithm. METHODS Retrospective analysis of the clinical, pathological and genetic features of 89 cases. RESULTS Three main phenotypes were found 'pure PEO' (42%), consisting of isolated palpebral ptosis with ophthalmoparesis; Kearns-Sayre syndrome (10%); and 'PEO plus', which associates extrao
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