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The year 2021 marks 100 years since the discovery of insulin and this Special Issue of the Journal of Neuroendocrinology was conceived as a way to mark that historic breakthrough. The discovery of insulin and its subsequent use in the treatment of diabetes is one of the most striking success stories in biomedical research. From a neuroendocrinology perspective, the recognition that insulin also exerts widespread and varied actions in the brain is more recent, but potentially also of equal importance with relevance for conditions ranging fro
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