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© 2020 The Authors.To day, the vast majority of intra-vital neuroimaging methods used in clinic and diagnostics is fixed with a rigid checking element, requires specialized facilities and expensive infrastructure. Right here, we describe an easy yet radical strategy for optoacoustic (photoacoustic) brain imaging in vivo using a light-weight handheld probe. It allows multispectral video-rate visualization of hemoglobin gradient changes in the cortex of person rats c

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