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Segmentation of brain tissue in diffusion MRI image space has some unique advantages. A novel segmentation method using the direction-averaged diffusion weighted imaging (DWI) signal is proposed. Two images can be obtained from the fitting of the direction-averaged DWI signal as a function of b-value one with superior contrast between the gray matter and white matter; one with prominent CSF contrast. A pseudo T1 weighted image can be constructed and standard segmentation tools can be applied. The method was tested on the HCP dataset usin

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