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We carried out a longitudinal evaluation of a cohort of 8571 clients using data produced from the Japan Dialysis Outcomes and application Patterns Study (J-DOPPS) phases 1 to 5. Associations of all-cause mortality, vascular events, and hospitalization because of illness with baseline MCV were examined via Cox proportional danger models. Non-linear interactions between MCV and these effects were examined utilizing limited cubic spline analyses. Organizations between time