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The present results reveal that therapy of cultured individual VSMCs with progesterone additionally the discerning mPR agonist Org OD-02-0 (OD 02- but not with all the nuclear PR agonist R5020 increased SERCA protein appearance, which was obstructed by knockdown of mPRα with siRNA. Additionally, treatments with progesterone and OD 02-0, however with R5020, enhanced phospholamban (PL phosphorylation, which may end in disinhibition of SERCA purpose. Progesterone and OD 02-0 sign

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