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For those two patients, PDX established from late tumors were more resistant to chemotherapy (irinotecan) than very early alternatives. On the other hand, the tumor set founded at refractory progression showed very dissimilar CNA pages, additionally the structure of response to chemotherapy was discordant with those of relapsed instances. In mice obtaining irinotecan infusions, the degree of SN-38 (active metabolite of irinotecan) into the intracellular tumor area was lower in tumors at later sta

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