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ADHD Treatment For Adults Stimulants like methylphenidate, amphetamine and other brain chemicals can aid in increasing levels. Non-stimulants such as atomoxetine and antidepressants work slower than stimulants, however, they can be just as beneficial. Comorbid conditions often affect the effectiveness of ADHD medication. Doctors should treat the most severe symptoms of any comorbid disorder first, then check to see if the ADHD symptoms improve. Medication