https://www.selleckchem.com/pr....oducts/bay-11-7082-b
As expected, there was a significant reduction in the percentage of proliferative cells that had PI3K inhibited. When compared to TKI 5 treatment, proliferating cells were significantly lower with simultaneous PI3K inhibition. CONCLUSION This study demonstrated that TKI-258 play an anti-proliferative role on SCC-4 cells of OSCC. It could be interesting to block multiples pathways such as FGFRs, PDGFRs and VEGFRs. Therefore, TKI-258 is a promising option for novel therapeutics for OSCC, especially if associated with PI3K
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