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Published by Elsevier on behalf of the American College of Cardiology Foundation. DOXO-induced endothelial dysfunction in conduit arteries is mediated by excessive mitochondrial ROS and ameliorated by mitochondrial-specific antioxidant treatment. Mitochondrial ROS is a viable therapeutic target for mitigating arterial dysfunction with DOXO. (J Am Coll Cardiol CardioOnc 2020;2475-88) © 2020 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. With increasing diagnoses and available treatment opt
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