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First Line Treatment For ADHD in Adults Some people with ADHD discover that medication can help to manage their symptoms. Stimulants such as methylphenidate or amphetamine work by increasing brain activity in the areas that regulate attention and behavior. Other medications, such as the nonstimulant drug atomoxetine, and antidepressants that work differently, yet are effective. Regular visits to the GP are recommended for people who are taking medication. T