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Leads to the bone structure of postmenopausal osteoporosis rats, the amount of phospho-PI3K (p-PI3K), p-Akt, and p-phosphoinositide-dependent kinase-1(PDK1) were notably decreased (p less then 0.05). In rat model osteoblasts, the overexpression of AK0 gene upregulated the phosphorylation level of AKT, whilst the disturbance with little interfering RNA (siRNA) in AK0 gene decreased that of AKT. Slamming out AK0 gene resulted in the down-regulation of
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