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How to Treat ADHD Without Medication Adults with ADHD may struggle to stay focused, feel irritable and be in a state of forgetfulness. They may also suffer from low self-esteem and relationships problems. Treatment without medication could involve lifestyle changes, such as eating healthy exercising regularly and learning relaxation techniques. It could also involve cognitive behavioral therapy which teaches people to recognize negative thoughts patterns and behaviors and then challenge them. 1. Talk Therapy Talk therapy (also known as psychotherapy