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The molecular docking and molecular dynamic simulation results of HSF1/Sch A suggested that Sch A formed key hydrogen bond and hydrophobic interactions with HSF1, which may contribute to its potent HSF1 inhibition. These findings provide clues for the design of novel HSF1 inhibitors and drug candidates for colon cancer treatment. © 2020 The Author(s).The article presents the effects of manoeuvring a wheelchair with manual pushrim propulsion on the position of the centre of gravity of the human body during wheelchair movement. Twenty seven propulsion

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