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Aqueous immunoglobulin G (IgG)1,2,3,4 and immunoglobulin A (IgA) were 2-4-fold higher in cases compared with controls. Disease-specific trends were observed, with diabetic retinopathy (DR) eyes containing the highest amounts of aqueous antibodies. Total number of injections correlated with higher titres of IgG1 (p less then 0.001), IgG2 (p less then 0.009), and IgG3 (p less then 0.001) in all cases analyzed with the strongest correlations seen in DR eyes (r = 0.77, p less then 0.001). Presence of aqueous humour antibodies correlated with

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