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With this study, sphere formation assay, flow cytometry, cell survival analysis, tube formation, 3D culture, immunoblot, mouse model, and luciferase reporter assay had been performed in vivo and in vitro. Expressions of SOX2 and miR-450a-5p in CRC structure samples had been analyzed through immunohistochemistry. First, the appearance of SOX2 was not only related to poor differentiation and prognosi
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