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71 days, 95% confidence interval (CI) -3.27 to -0.14 days compared to placebo] and the second highest response rate (odds ratio = 4.19, 95% CI = 1.46 to 12.00 compared to placebo). Furthermore, oral melatonin 3 mg (immediate-release) at bedtime was the most preferred pharmacologic intervention among all of the investigated interventions when improvements in migraine frequency, response rate, drop-out rate, and rates of any adverse events were taken into account. This pilot NMA suggests the potential prophylactic role of exogeno