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The activation of the Wnt/β-catenin pathway protected against the impairment of intestinal permeability induced by maternal vitamin D deficiency. CONCLUSIONS Maternal vitamin D deficiency increased intestinal permeability and decreased tight junction protein expression in offspring. The suppression of the Wnt/β-catenin signaling pathway through histone modification might be involved in the underlying mechanism. © 2020 American Society for Parenteral and Enteral Nutrition.Calcium metal batteries (CMBs) provide a promising option for high