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A thorough analysis of this effectiveness and safety of every intervention is needed to notify medical decision-making. This research aimed at evaluating the effectiveness and safety of various treatments for LPS. METHODS PubMed, Embase, ScienceDirect, ClinicalKey, Cochrane Library, ProQuest, Web of Science, and ClinicalTrials.gov were searched from creation to December 6th 2018. Just randomized controlled trials (RCTs) including the clients m