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In animal studies on bone healing, the effect of housing space and physical activity are seldom taken into account. Bone formation was evaluated in New Zealand White rabbits (mean ± SEM BW 3.9 ± 0.11 kg) with a critical bone defect after 12 weeks of rehabilitation in pair-housing in 3 m2 large floor pens (Floor, n = 1 or standard single housing in 0.43 m2 cages (Cage, n = 1. In the randomised full-factorial study, a bone replica of calcium phosphate cement (CPC, n = 1 or autologous bone (AB, n = 1 was implanted in the unilatera

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