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Untreated ADHD in Adults Can Lead to Feelings of Worthlessness and Depression Untreated ADHD can result in chronic underachievement and depression. This is especially the case when they don't achieve their goals in terms of personal and professional. Diagnoses are difficult to establish when there are commonalities in symptoms between ADHD and depression. However, identifying the signs is the first step toward getting treatment. 1. Feelings of inadequacy Many people with untreated ADHD or depression co-occurring with it are plagued by feelings of inadequateness and d