https://www.selleckchem.com/pr....oducts/muvalaplin.ht
WD-fed mice receiving anti-PD-1 had more prominent ear swelling than lean mice receiving anti-PD-1 during the 5-day IMQ course (2-fold increase, P less then 0.0001 on day 5). CONCLUSION WD-induced obesity enhances IMQ-induced psoriasiform inflammation. The finding that WD-fed mice have a more dramatic response to anti-PD-1 than lean mice in terms of IMQ-induced ear swelling suggests that obesity could be a risk factor in the development of psoriasiform eruption during anti-PD-1 therapy. V.BACKGROUND Lymphocytic thrombophilic arteri
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