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but the rates of IVIG resistance (RR, 1.26; 95% CI 0.55, 2.92; P = 0.59; random-effects model) and days in hospital (MD, 0.22; 95% CI -0.93, 1.37; P = 0.71; random-effects model) were similar between the two groups. CONCLUSION Low-dose aspirin plus IVIG might be as effective as high-dose aspirin plus IVIG for the initial treatment of Kawasaki disease. Considering that high-dose aspirin may cause more adverse reactions than low-dose aspirin, low-dose aspirin plus IVIG should be recommended as the first-line therapy in the initial treatme

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