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ADHD Treatment For Adults Stimulants such as methylphenidate, amphetamine and other brain chemicals can help increase levels. Non-stimulants like atomoxetine, antidepressants, or work slower than stimulants, but they may be just as helpful. Comorbid conditions can affect the response of ADHD medication. Doctors should treat the most severe symptoms of any comorbid disorder first, and then examine whether the ADHD symptoms improve. Medicatio