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Our results reveal how low-mechanical stress affects 2D layered perovskite aggregation and orientation, an open pathway toward the design of strain-controlled emission.The second near-infrared (NIR-II) window (1000-1350 nm) usually offers further improved light penetration, a higher maximum permissible exposure (MPE), and a lower background signal. Development of NIR-II optical diagnosis and phototherapy technologies is of great significance for precise, efficient tumor therapy. In this work, a new type of Ti-based targeting agent (B-TiO
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